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Article

Phenotypic and genotypic characterization of Plasmodium falciparum field isolates lacking pfhrp2 gene.

Malaria journal - 16 Mar 2026

Bendezu Jorge, Larrauri-Aguilar Paola, Bautista Ronald, Villasis Elizabeth, Vinetz Joseph M, Gamboa Dionicia

Abstract excerpt

BACKGROUND: The Plasmodium falciparum phenotypic characteristics (cytoadherence and rosetting), and the concentration of Histidine Rich Protein 2 (HRP2) in serum are associated with severe malaria in regions like Africa and Asia. Also, HRP2 has recently been associated as a P. falciparum virulence factor. Parasites lacking pfhrp2 gene were first reported in the Peruvian Amazon, however, there are not yet reports...

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PMID: 41840576
DOI: 10.1186/s12936-026-05860-w
PMCID: PMC13104473

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