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Genetic, Epigenetic, and Immunologic Profiling of MMR-Deficient Relapsed Glioblastoma

4 Dec 2018

Abstract excerpt

Abstract Purpose: In-depth characterization of recurrent glioblastoma (rGBM) might contribute to a better understanding of the mechanisms behind tumor progression and enable rGBM treatment with targeted drugs. Experimental Design: In this study, GBM samples were collected at diagnosis and recurrence from adult patients treated with Stupp protocol. Expression of mismatch repair (MMR) proteins was evaluated by IHC,...

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PMID: 30514778
DOI: 10.1158/1078-0432.ccr-18-1892

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