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Article

The ribosome-associated N-terminal acetyltransferase B coordinates global proteostasis and autophagy in plants by creating Ac/N-degrons.

Nature communications - 31 Mar 2026

Gong Xiaodi, Pożoga Marlena, Boyer Jean-Baptiste, Xue Yuxing, Meinnel Thierry, Bange Tanja, Giglione Carmela, Hell Rüdiger, Wirtz Markus

Abstract excerpt

The N-terminal acetyltransferase B (NatB) acetylates ~20% of the eukaryotic proteome. However, the role of NatB-mediated N-terminal acetylation (NTA) for the regulation of the proteome fate remains unclear in eukaryotes. In this study, we demonstrate that CRISPR-Cas9-mediated deletion of NatB activity in plants results in significantly lowered global protein turnover due to decreased ubiquitin-proteasome system...

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Identifiers

PMID: 41917016
DOI: 10.1038/s41467-026-71208-2
PMCID: PMC13039445

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