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Impact of mutations on the stability of SARS-CoV-2 nucleocapsid protein structure.

Scientific reports - 11 Mar 2024

Muradyan Nelli, Arakelov Vahram, Sargsyan Arsen, Paronyan Adrine, Arakelov Grigor, Nazaryan Karen

Abstract excerpt

The nucleocapsid (N) protein of SARS-CoV-2 is known to participate in various host cellular processes, including interferon inhibition, RNA interference, apoptosis, and regulation of virus life cycles. Additionally, it has potential as a diagnostic antigen and/or immunogen. Our research focuses on examining structural changes caused by mutations in the N protein. We have modeled the complete tertiary structure of...

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COVID-19
Mutation
Nucleocapsid
Nucleocapsid Proteins
SARS-CoV-2

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PMID: 38467657
DOI: 10.1038/s41598-024-55157-8
PMCID: PMC10928099

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