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Canine Urothelial DNA Mutations Are Not Associated With Total Trihalomethanes Concentrations in Municipal Drinking Water.

Veterinary and comparative oncology - 1 Jun 2026

O'Brien Janice, Braman Samantha L, Willcox Jennifer, Wang Phillip, Gerrity Daniel, Ruple Audrey, Trepanier Lauren A

Abstract excerpt

Contaminants in municipal drinking water, specifically total trihalomethanes (TTHMs), are mutagenic. Exposures to TTHMs have been associated with urothelial carcinoma (UC) in both people and dogs. Mutations in the BRAF gene and other genomic copy number aberrations detected in voided urothelial cells with commercial CADET BRAF and BRAF-PLUS tests have also been associated with the presence of UC in dogs. However,...

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PMID: 41816851
DOI: 10.1111/vco.70060
PMCID: PMC13161735

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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