Article
Naturally occurring canine laminopathy leading to a dilated and fibrosing cardiomyopathy in the Nova Scotia Duck Tolling Retriever.
Scientific reports - 4 Nov 2023
Bannasch Danika L, Oertle Danielle T, Vo Julia, Batcher Kevin L, Stern Joshua A, Kaplan Joanna L, Li Ronald H L, Madden Indiana E, Christen Matthias, Leeb Tosso, Joshi Nikhil
Abstract excerpt
Dilated cardiomyopathy (DCM) is characterized by decreased systolic function and dilation of one or both ventricles, often leading to heart failure or sudden death. Two 10-month-old sibling Nova Scotia Duck Tolling Retrievers (NSDTR) died acutely with evidence of dilated cardiomyopathy with myocardial fibrosis. Association analysis using two cases and 35 controls identified three candidate regions homozygous in...
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