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Finding the genetic basis of adaptation: reducing complexity to improve trait mapping.

Current opinion in genetics & development - 1 Apr 2026

Yarkhunova-Kreye Yulia, Hancock Angela M

Abstract excerpt

Genome-wide association studies (GWAS) have advanced our understanding of trait variation, yet persistent challenges limit their effectiveness in mapping adaptive traits. Population structure, allelic heterogeneity, trait complexity, and structural variation obscure true causal relationships. However, these factors can often be addressed through strategic simplification. Here, we review factors limiting GWAS...

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Adaptation, Physiological
Arabidopsis
Chromosome Mapping
Genome-Wide Association Study
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Quantitative Trait Loci

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PMID: 41558241
DOI: 10.1016/j.gde.2025.102432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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