Drosophila models of Parkinson's disease.

Abstract excerpt

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder principally affecting the dopaminergic neurons of the substantia nigra. The pathogenic mechanisms are unknown and there are currently no cure or disease-modifying therapies. Recent genetic linkage studies have begun to identify single-gene mutations responsible for rare heritable forms of PD and define genetic risk factors...

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• Sequence Homology
• Small Molecule Libraries
• Drosophila melanogaster
• Drosophila Proteins
• Gene Expression
• Genetic Testing