Integration of scRNA-Seq and Bulk RNA-Seq Identifies Circadian Rhythm Disruption-Related Genes Associated with Prognosis and Drug Resistance in Colorectal Cancer Patients

Abstract excerpt

Background: Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. With the increasing incidence of CRC, there is an urgent need for effective strategies for early diagnosis and treatment. Circadian rhythm, a natural biological clock, regulates various physiological processes, and its disruption has been implicated in the onset and progression of cancer. However, the specific roles of...

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