Functional investigation of the RHD gene promoter: Molecular changes are rarely responsible for variant D phenotype in Thai donors.

Abstract excerpt

BACKGROUND: While modern technology is increasingly available to identify efficiently the molecular alterations responsible for variant phenotype, a subset of samples still escapes those analyses. In addition to the promoter region, two intronic regions containing GATA1 binding sites within the RHD gene locus were recently shown to modulate the transcriptional activity of the gene. We then thought to explore...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blood Donors
• Share to GATA1 Transcription Factor
• Share to Genetic Variation