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Article

Promoter polymorphisms in the JK*01 W.06 allele associated with the Jk(a + w) weak antigen phenotype.

BMC immunology - 8 Jun 2025

Liang Shuang, Wu Fan, Jiang Renhui, Liu Tong, Sun Liyan, Tang Rong, Dang Yingnan, Deng Zhihui

Abstract excerpt

BACKGROUND: The Kidd blood group system is critical in transfusion medicine, especially for delayed hemolytic reactions. However, the genetic background and molecular mechanisms underlying the weak antigen phenotype remain unclear. This study aimed to elucidate how the JK*01 W.06 allelic variant and its promoter region polymorphisms contribute to reduced Jka antigen expression in the weak antigen phenotype....

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Identifiers

PMID: 40484950
DOI: 10.1186/s12865-025-00727-2
PMCID: PMC12147333

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