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Article

Bidirectional Mendelian randomization analysis of the causal association between obesity and hepatocellular carcinoma in a European population.

Medicine - 6 Mar 2026

Ding Xiaoling, Zhou Xuebing, Tang Ning, Wang Xue, Jin Xuerong, Ma Xin, Wu Banglong, Wu Chaomeng, Yang Xia, Yang Jie, Wu Tong, Liang Qi, Yin Lijun

Abstract excerpt

This study aimed to investigate the causal relationship between obesity and hepatocellular carcinoma (HCC) using bidirectional Mendelian randomization (MR). We employed a 2-sample bidirectional MR approach using genome-wide association study summary statistics from the FinnGen consortium. Body mass index (BMI) was selected as the exposure variable for the forward MR analysis, while HCC was examined as the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41790622
DOI: 10.1097/MD.0000000000048000
PMCID: PMC12975235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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