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Article

Genomic landscape of stage 0-IA lung adenocarcinoma identified by on-site reflex targeted NGS.

Lung cancer (Amsterdam, Netherlands) - 1 Mar 2026

Ilié Marius, Heeke Simon, Rignol Guylène, Pirlog Radu, Goffinet Samantha, Long-Mira Elodie, Lassalle Sandra, Lespinet-Fabre Virginie, Bordone Olivier, Tanga Virginie, Lacoux Caroline, Bonnetaud Christelle, Benzaquen Jonathan, Boutros Jacques, Cohen Charlotte, Gomez-Caro Abel, Marquette Charles Hugo, Berthet Jean-Philippe, Hofman Véronique, Hofman Paul

Abstract excerpt

INTRODUCTION: Early molecular profiling in non-squamous non-small cell lung carcinoma (NSCLC), particularly lung adenocarcinoma (LUAD), is critical for guiding individualized treatment strategies. Limited data exist on the genomic landscape of Stage 0-IA LUAD. This study assessed the feasibility and clinical relevance of reflex targeted next-generation sequencing (NGS) performed on-site at diagnosis in resected...

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Identifiers

PMID: 41671632
DOI: 10.1016/j.lungcan.2026.108943

Genes

KRAS
ALK
BRAF
EGFR
MET
RET
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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