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Article

Genomic landscape, immune microenvironment and survival in male versus female breast cancer.

ESMO open - 1 Mar 2026

Trapani D, Deshmukh S K, Samec T, Wu S, Xiu J, Walker P, Abravanel D L, Advani P, Spanheimer P M, Lin N U, Curigliano G, Graff S L, Lustberg M, Sledge G W, Tolaney S M, Leone J P

Abstract excerpt

BACKGROUND: Male breast cancer (MaBC) represents ∼1% of breast malignancies and may have significant differences to female BC (FeBC) that impact prognosis and treatment response. In this work, we sought to characterize the molecular and immune landscape of MaBC. MATERIALS AND METHODS: We analyzed whole-transcriptome (WTS) and whole exome sequencing from 19 697 deidentified tumor samples provided to Caris Life...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41785670
DOI: 10.1016/j.esmoop.2026.106059
PMCID: PMC12972996

Genes

BRCA2
CDH1
ESR1
LAG3
PDCD1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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