Article
Gadolinium enhancement of the cauda equina in a case of familial ALS with p.S135G SOD1 mutation.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Aug 2026
Nomizo Sumika, Komatsu Junji, Shima Ayano, Muramatsu Daiki, Matsubara Keitaro, Nozaki Ichiro, Noguchi-Shinohara Moeko, Nishiyama Ayumi, Suzuki Naoki, Aoki Masashi, Ono Kenjiro
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor neuron degeneration. Gadolinium enhancement of the cauda equina is typically associated with inflammatory diseases. We report a case of familial ALS with a Cu/Zn superoxide dismutase (SOD1) gene mutation showing marked gadolinium enhancement of the lumbar nerve roots. To date, only a few cases of ALS with...
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