Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thymidine phosphorylase facilitates retinoic acid inducible gene-I induced endothelial dysfunction

26 Apr 2023

Abstract excerpt

Activation of nucleic acid sensors in endothelial cells (ECs) has been shown to drive inflammation across pathologies including cancer, atherosclerosis and obesity. We previously showed that enhancing cytosolic DNA sensing by inhibiting three prime exonuclease 1 (TREX1) in ECs led to EC dysfunction and impaired angiogenesis. Here we show that activation of a cytosolic RNA sensor, Retinoic acid Induced Gene 1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to Retinoids in leukemia and cellular processes
Share to Systemic Lupus Erythematosus Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37100811
DOI: 10.1038/s41419-023-05821-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thymidine phosphorylase facilitates retinoic acid inducible gene-I induced endothelial dysfunctionPMID 37100811Read ↗

Human retinoic acid-inducible gene I (RIG-I) deficiency associated with susceptibility to classic Kaposi sarcoma.Semantic proximity Read ↗

RIG-I Detects Kaposi’s Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent MannerSemantic proximity Read ↗

RSAD2: A pathogenic interferon-stimulated gene at the maternal-fetal interface of patients with systemic lupus erythematosusSemantic proximity Read ↗

Human RIG-I deficiency confers susceptibility to Kaposi Sarcoma via loss of latency controlSemantic proximity Read ↗

Type I interferon-mediated autoinflammation due to DNase II deficiency.Semantic proximity Read ↗

Alterations in genes associated with cytosolic RNA sensing in whole blood are associated with coronary microvascular disease in SLESemantic proximity Read ↗

Endothelial Ribonuclease 1 in Cardiovascular and Systemic InflammationSemantic proximity Read ↗

Regnase‐1–related endoribonucleases in health and immunological diseasesSemantic proximity Read ↗

Friend or foe: RIG- I like receptors and diseasesSemantic proximity Read ↗

Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes.Semantic proximity Read ↗

CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profilingSemantic proximity Read ↗

From DNA Repair to Redox Signaling: The Multifaceted Role of APEX1 (Apurinic/Apyrimidinic Endonuclease 1) in Cardiovascular Health and DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.