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Article

Are Genetics Useful to Guide Ablation Strategies in Patients With Persistent Atrial Fibrillation?

Journal of cardiovascular electrophysiology - 1 May 2026

Lim Michael W, Kistler Peter M, Curtin Annie G, Chieng David, William Jeremy, Segan Louise, Crowley Rose, Soka Magdalena J, Young Paul E, Rath Emma M, Yu Chenglong, Ohanian Monique, Johnson Renee, Lacaze Paul, Giannoulatou Eleni, Voskoboinik Aleksandr, Prabhu Sandeep, Sugumar Hariharan, Fatkin Diane, Kalman Jonathan M

Abstract excerpt

BACKGROUND: In the CAPLA trial, arrhythmia-free survival did not differ between patients with persistent atrial fibrillation (AF) who underwent pulmonary vein isolation (PVI) with posterior wall isolation (PWI) vs. PVI alone. High AF polygenic risk scores (PRS) have been associated with increased left atrial substrate and arrhythmia recurrence post-ablation. Whether AF patients with high AF-PRS benefit from a...

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Identifiers

PMID: 41779611
DOI: 10.1111/jce.70297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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