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Article

Risks of non-breast, non-ovarian cancers for BRCA1 and BRCA2 pathogenic variant carriers: a prospective cohort study.

BMC medicine - 4 Mar 2026

Yang Ruotong, MacInnis Robert J, Milne Roger L, Nguyen-Dumont Tu, Maxwell Whitney F, Genkinger Jeanine M, Glendon Gord, Ross Eric A, Andrulis Irene L, Colonna Sarah V, Daly Mary, John Esther M, Kurian Allison W, Terry Mary Beth, Hopper John L, Southey Melissa C, Phillips Kelly-Anne, Li Shuai

Abstract excerpt

BACKGROUND: The non-breast non-ovarian cancers associated with BRCA1 and BRCA2 pathogenic variants (PVs) are controversial. We aimed to examine this using a prospective cohort design. METHODS: This study included 1260 BRCA1 and 1058 BRCA2 PV carriers (91% were females) from two consortia: the Breast Cancer Family Registry (BCFR) and the Kathleen Cuningham Foundation Consortium for Research into Familial Breast...

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Identifiers

PMID: 41776557
DOI: 10.1186/s12916-026-04753-8
PMCID: PMC13067437

Genes

BRCA1
BRCA2
FUS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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