Article
Novel EPS15 :: KLF17 and EPS15L1 :: KLF17 Fusions Define a Distinctive Group of MUC4-Positive Spindled to Epithelioid Sarcomas.
The American journal of surgical pathology - 1 May 2026
Malik Faizan, Vong Maia, Dehner Carina A, Shi Zonggao, Karanian Marie, Pissaloux Daniel, Pinto Soniya N, Blackburn Patrick R, Tran Quynh T, Orr Brent A, Koo Selene C
Abstract excerpt
A subset of epithelioid-to-spindle cell sarcomas remains difficult to classify due to lack of defining molecular alterations or pathologic features that do not fit neatly into a single tumor class. After identification of a primary mesenchymal neoplasm with EPS15L1::KLF17 gene fusion, we retrospectively collected 4 additional soft tissue tumors with EPS15L1 :: KLF17 or EPS15 :: KLF17 fusions. The cohort comprised...
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