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Article

Genetic architecture of heart failure with preserved versus reduced ejection fraction

14 Dec 2022

Abstract excerpt

Pharmacologic clinical trials for heart failure with preserved ejection fraction have been largely unsuccessful as compared to those for heart failure with reduced ejection fraction. Whether differences in the genetic underpinnings of these major heart failure subtypes may provide insights into the disparate outcomes of clinical trials remains unknown. We utilize a large, uniformly phenotyped, single cohort of...

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PMID: 36517512
DOI: 10.1038/s41467-022-35323-0

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