Article
Respiratory Syncytial Virus Nonstructural Protein 1 Inhibits Production of Cytokines and Chemokines by Differentiated Primary Nasal Epithelial Cells Cultured at Air-Liquid Interface.
Journal of innate immunity - 1 Jan 2026
Koutstaal Rosanne W, Munoz Garcia Amadeo, Ebert Nadine, Licheri Manon F, Lakerveld Anke J, Hamstra Hendrik-Jan, Gelderloos Anne T, de Jonge Jørgen, van Els Cécile A C M, Thiel Volker, Dijkman Ronald, van Kasteren Puck B
Abstract excerpt
INTRODUCTION: Respiratory syncytial virus (RSV) is a major cause of severe respiratory infections in children and older adults. Currently, approved vaccines target only the viral fusion protein, but live-attenuated vaccines - e.g., through inactivation of nonstructural protein 1 (NS1) - likely induce a broader immune response. NS1 inhibits the immune response by repressing interferon production, but this has...
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