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Article

The longevity factor spermidine is part of a highly heritable complex erythrocyte phenotype associated with longevity.

Aging cell - 1 Dec 2024

Kaminsky Cameron J, Mill Jericha, Patel Viharkumar, Pierce Dylan, Haj Amelia, Hess Aaron S, Li Lingjun, Raife Thomas

Abstract excerpt

Extreme longevity in humans is known to be a heritable trait. In a well-established twin erythrocyte metabolomics and proteomics database, we identified the longevity factor spermidine and a cluster of correlated molecules with high heritability estimates. Erythrocyte spermidine is 82% heritable and significantly correlated with 59 metabolites and 22 proteins. Thirty-eight metabolites and 19 proteins were >20%...

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Identifiers

PMID: 39243176
DOI: 10.1111/acel.14311
PMCID: PMC11634715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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