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Article

Improving the Thermostability of the Qβ Bacteriophage Coat Protein Through Single-Site Mutation Based on Molecular Dynamics.

International journal of molecular sciences - 8 Feb 2026

Qu Meng, Li Mingyu, Sun Jing, Jiang Yanhua, Zhu Wenjia, Guo Yingying, Li Na, Wang Dapeng, Yao Lin

Abstract excerpt

Norovirus is a major cause of acute viral gastroenteritis in humans. Molecular biology-based detection methods play a pivotal role in ensuring accurate and specific diagnosis. The inclusion of Qβ phage particles as armored positive controls in these assays can further enhance their reliability and specificity. Herein, we discuss rational design strategies to improve the stability of Qβ bacteriophage capsid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41751790
DOI: 10.3390/ijms27041648
PMCID: PMC12940326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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