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Article

Integrated Transcriptomic and Histological Analysis of TP53/CTNNB1 Mutations and Microvascular Invasion in Hepatocellular Carcinoma.

Genes - 3 Feb 2026

Garach Ignacio, Hernandez Nerea, Herrera Luis J, Ortuño Francisco M, Rojas Ignacio

Abstract excerpt

Background/Objectives: Hepatocellular carcinoma (HCC) shows marked molecular and histopathological heterogeneity. Among the alterations most strongly associated with clinical outcome are mutations in TP53 and CTNNB1, as well as the presence of microvascular invasion (MVI). Although these factors are well established as prognostic indicators, how their molecular effects relate to tumor morphology remains unclear....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41751574
DOI: 10.3390/genes17020190
PMCID: PMC12940783

Genes

CTNNB1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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