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Article

MRI based unsuperviced clustering on MIBC reveals intratumor heterogeneity phenotypes and neoadjuvant chemotherapy efficacy.

Cancer imaging : the official publication of the International Cancer Imaging Society - 25 Feb 2026

Zhang Yuheng, Cai Lingkai, Chen Yuhan, Bai Rongjie, Wang Chenghao, Tan Zhengye, Chen Chang, Liu Xiaotong, Liang Bo, Jiang Meihua, Wang Gongcheng, Shao Qiang, Jiang Xuping, Bao Meiling, Yu Hao, Cao Qiang, Yang Xiao, Lu Qiang

Abstract excerpt

BACKGROUND: To develop and validate a non-invasive imaging-based intratumor heterogeneity (IITH) framework for risk stratification in muscle-invasive bladder cancer (MIBC) and to investigate its association with survival outcomes and molecular subtypes. METHODS: In this retrospective multicenter study, 437 MIBC patients were enrolled (237 patients of discovery cohort and 102 patients of validation cohort...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41742305
DOI: 10.1186/s40644-026-01007-x
PMCID: PMC13040948

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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