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Article

A Gene for Speed: The Emerging Role of α-Actinin-3 in Muscle Metabolism

1 Aug 2010

Abstract excerpt

A common polymorphism (R577X) in the ACTN3 gene results in complete deficiency of alpha-actinin-3 protein in approximately 16% of humans worldwide. The presence of alpha-actinin-3 protein is associated with improved sprint/power performance in athletes and the general population. Despite this, there is evidence that the null genotype XX has been acted on by recent positive selection, likely due to its emerging...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20699471
DOI: 10.1152/physiol.00008.2010

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