Article
Lower airway immunophenotyping in severe preschool wheeze reveals distinct clusters described by heterogeneity in neutrophil phenotypes.
American journal of respiratory and critical care medicine - 1 Apr 2026
Bonner Katie L, Fontanella Sara, Gore Mindy, Cook James, Hoffland Ashley, Scotney Elizabeth, Tian Kunyuan, Hillson Kushalinii, Shamji Mohamed, Layhadi Janice, Al-Kuwari Haya, Bush Andrew, Custovic Adnan, Lloyd Clare M, Saglani Sejal
Abstract excerpt
RATIONALE: Recurrent preschool wheeze accounts for most childhood hospitalizations for asthma and often responds poorly to inhaled corticosteroids (ICSs). OBJECTIVE: To relate lower airway immune cell composition in children with recurrent severe wheeze (RSW) to infection, allergic sensitization, and prescribed treatments. METHODS: Children with RSW aged 1 to 5 years underwent clinical phenotyping, bronchoscopy,...
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