Article
Novel Treatment-Refractory Preschool Wheeze Phenotypes Identified by Cluster Analysis of Lung Lavage Constituents.
The journal of allergy and clinical immunology. In practice - 1 Jul 2021
Teague W Gerald, Lawrence Monica G, Williams Sanford, Garrod Andrea S, Froh Deborah, Early Stephen V, Brand William, Middleton Jeremy P, Mendoza Michael V, Hollis Kerry A, Wavell Kristin, Heymann Peter W, Steinke John W, Borish Larry
Abstract excerpt
BACKGROUND: Preschool children with treatment-refractory wheeze often require unscheduled acute care. Current guidelines advise treatment of persistent wheeze with inhaled corticosteroids. Alternative treatments targeting structural abnormalities and specific inflammatory patterns could be more effective. OBJECTIVE: To apply unsupervised analysis of lung lavage (bronchoalveolar lavage [BAL]) variables to identify...
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