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Article

Recurrent Severe Preschool Wheeze: From Prespecified Diagnostic Labels to Underlying Endotypes.

American journal of respiratory and critical care medicine - 1 Sept 2021

Robinson Polly F M, Fontanella Sara, Ananth Sachin, Martin Alonso Aldara, Cook James, Kaya-de Vries Daphne, Polo Silveira Luisa, Gregory Lisa, Lloyd Clare, Fleming Louise, Bush Andrew, Custovic Adnan, Saglani Sejal

Abstract excerpt

Rationale: Preschool wheezing is heterogeneous, but the underlying mechanisms are poorly understood.Objectives: To investigate lower airway inflammation and infection in preschool children with different clinical diagnoses undergoing elective bronchoscopy and BAL.Methods: We recruited 136 children aged 1-5 years (105 with recurrent severe wheeze [RSW]; 31 with nonwheezing respiratory disease [NWRD]). Children...

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Identifiers

PMID: 33961755
DOI: 10.1164/rccm.202009-3696OC
PMCID: PMC8491264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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