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Article

Viral triggers and genetic predisposition in ocular autoimmunity: unraveling the breakdown of immune privilege and advancing targeted therapeutics.

Molecular aspects of medicine - 1 Apr 2026

Bai Jianhao, Wu Zhiyong, Wan Zhongqi, Zhao Chun, Liu Yin, Wang Tianyu

Abstract excerpt

The eye maintains vision through a distinctive immune privilege, utilizing physical barriers and active immunosuppression mediated by molecules such as FasL and PD-L1, as well as cells, including regulatory T cells and RPE cells. The emergence of sight-threatening immune-mediated ocular diseases, including non-infectious uveitis, signifies a significant disruption of this tolerance. This review analyzes the role...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41724162
DOI: 10.1016/j.mam.2026.101457

Genes

RPE
AIRE
IDO1
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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