A transcriptomic dimension of neuronal and immune gene programs within the subgenual anterior cingulate cortex in schizophrenia.

Abstract excerpt

Many psychiatric disorders are heritable, but the molecular consequences of genetic risk remain difficult to resolve, in part due to environmental confounds and the complexity of transcriptomic data. This challenge impedes therapeutic development, which relies on integrating genetic and genomic insights. Here, we integrate diagnosis, toxicological exposure, and gene expression to clarify disease-associated...

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