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Article

α-Thalassemia has no association with asymptomatic Plasmodium falciparum carriage in three ecological zones of Ghana.

Scientific reports - 18 Feb 2026

Donkor Augustine Boakye, Bernasko Frank George, Abdulai Anisa, Eyeson Nana Aba Sertowu, Abban Raphael Lartey, Boadu Elaine Asiwome, Kusi Kwadwo Asamoah, Afrane Yaw Asare, Amoah Linda Eva

Abstract excerpt

α-thalassemia, a hereditary disorder, common in malaria-endemic regions, provides selective advantage by conferring partial protection against severe Plasmodium falciparum malaria. This study investigated the distribution of α-thalassemia genotypes and Plasmodium falciparum carriage among 1401 asymptomatic individuals aged 1-60 years, across Ghana's coastal, forest, and Sahel savanna ecological zones. DNA was...

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Identifiers

PMID: 41708680
DOI: 10.1038/s41598-026-38080-y
PMCID: PMC13013582

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