Article
APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study.
The Lancet. Neurology - 1 Aug 2011
Biffi Alessandro, Anderson Christopher D, Jagiella Jeremiasz M, Schmidt Helena, Kissela Brett, Hansen Björn M, Jimenez-Conde Jordi, Pires Caroline R, Ayres Alison M, Schwab Kristin, Cortellini Lynelle, Pera Joanna, Urbanik Andrzej, Romero Javier M, Rost Natalia S, Goldstein Joshua N, Viswanathan Anand, Pichler Alexander, Enzinger Christian, Rabionet Raquel, Norrving Bo, Tirschwell David L, Selim Magdy, Brown Devin L, Silliman Scott L, Worrall Bradford B, Meschia James F, Kidwell Chelsea S, Broderick Joseph P, Greenberg Steven M, Roquer Jaume, Lindgren Arne, Slowik Agnieszka, Schmidt Reinhold, Woo Daniel, Rosand Jonathan
Abstract excerpt
BACKGROUND: Carriers of APOE ε2 and ε4 have an increased risk of intracerebral haemorrhage (ICH) in lobar regions, presumably because of the effects of these gene variants on risk of cerebral amyloid angiopathy. We aimed to assess whether these variants also associate with severity of ICH, in terms of haematoma volume at presentation and subsequent outcome. METHODS: We investigated the association of APOE ε2 and...
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