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Article

Apolipoprotein E genotype does not influence the risk of symptomatic hemorrhage in acute ischemic stroke.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia - 1 Jun 2021

Tábuas-Pereira Miguel, Galego Orlando, Almeida Maria Rosário, Tomás José, Félix-Morais Ricardo, Silva Fernando, Rodrigues Bruno, Cordeiro Gustavo, Sargento-Freitas João

Abstract excerpt

BACKGROUND: APOE ε4 is independently associated with lobar intracranial hemorrhages (ICH). Although the ε4 allele enhances amyloid deposition in blood vessels, the ε2 allele predisposes to vasculopathic changes leading to rupture of amyloid laden vessels. Thus, ε4 and ε2 carriers might have increased susceptibility to ICH. We aimed to study the impact of the apolipoprotein E alleles in the development of...

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PMID: 33992200
DOI: 10.1016/j.jocn.2021.03.014

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