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Article

Identification of a nucleotide deletion at the flanking sequence of D12S391 that causes allelic imbalance and inter-kit discordance.

Forensic science international - 1 Jun 2026

Zhang Guoan, Sun Qianqian, Chu Yi, Xu Mei, Sun Runsheng, Zhang Wenzhe, Zhang Jinqiu, Dang Zhen, Hou Sen, Wang Yequan

Abstract excerpt

Capillary electrophoresis is widely used to study short tandem repeats (STRs) in forensic genetics. This study investigated the molecular mechanisms underlying allelic imbalance and inter-kit genotyping discordance at the D12S391 locus in a parentage testing case. The Huaxia Platinum Kit exhibited severe allelic imbalance at the D12S391 locus (alleles '18, 25', peak height ratio = 16.40 %), whereas the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41707407
DOI: 10.1016/j.forsciint.2026.112892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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