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One sample, three genotypes: A flanking region deletion at the D19S433 locus causes genotyping discrepancies between CE and NGS technologies.

Forensic science international. Genetics - 1 Jun 2025

Carbó-Ramírez Sandra, Codoñer-Alejos Alan, Reyes-Prieto Mariana, Bernat Cristina, Gil Anabel, Ruiz-Ramírez Jorge, Soriano-Chirona Vicente, Marco-Romero Griselda De, Gonzalez-Candelas Fernando, Martinez-Priego Llúcia

Abstract excerpt

Short tandem repeats (STRs) are widely used in forensic genetics for individual identification. While traditional STR analysis relies on capillary electrophoresis (CE), next-generation sequencing (NGS) offers advantages such as full allelic sequence resolution, improving sensitivity and discrimination power. However, genetic variations in flanking regions can lead to discordant genotyping results between CE and...

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Topics

Humans
High-Throughput Nucleotide Sequencing
Electrophoresis, Capillary
Microsatellite Repeats

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genotype

DNA Fingerprinting

Sequence Analysis, DNA

Sequence Deletion

Polymerase Chain Reaction

Source

Identifiers

PMID: 40412064
DOI: 10.1016/j.fsigen.2025.103301

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