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Article

Characterization of STRC Gene Conversions by Nanopore Sequencing.

Clinical chemistry - 5 May 2026

Rigon Chiara, Sorrentino Ugo, Volta Sara, Prevedello Francesco, Trevisson Eva, Salviati Leonardo, Viscomi Carlo, Cassina Matteo

Abstract excerpt

BACKGROUND: Biallelic loss-of-function variants of STRC are a frequent cause of mild to moderate nonsyndromic hearing loss. The high (>98%) sequence homology between STRC and its pseudogene STRCP1 poses a significant challenge for accurate interpretation of STRC variants using standard methods. Although STRC-STRCP1 gene conversions have frequently been inferred from next-generation sequencing and copy number...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41696978
DOI: 10.1093/clinchem/hvag004

Genes

STRC
CKMT1B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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