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Article

Overproduction of glycolipopeptide bio-amphiphile by Pseudomonas aeruginosa mutant generated through three-tier cocktail random mutagenesis.

BMC microbiology - 14 Feb 2026

Ekpenyong Maurice, Edet Philomena, Onwugbuta-Kingsley Ifeoma, Agba Linda, Ekpo Bassey, Antai Sylvester

Abstract excerpt

A robust three-tier cocktail of random mutagenesis involving atmospheric and room temperature plasma, gamma-rays, and N-methyl-N'-nitro-N-nitrosoguanidine exposures was applied to induce glycolipopeptide overproduction in Pseudomonas aeruginosa strain IKW1 (GenBank Accession No.: PV664482.1). Auxanographic investigations suggested unrepaired metabolic blocking of the threonine, and hence, isoleucine branches of...

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Identifiers

PMID: 41691164
DOI: 10.1186/s12866-026-04721-5
PMCID: PMC13011539

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