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Multidomain DNA-Protein Mining Reveals Polymorphic Variations in RhlB Enhancing Monorhamnolipid Biosynthesis.

ACS synthetic biology - 15 May 2026

Trus Pavlos, Chang Chien-Yi

Abstract excerpt

Rhamnolipids are glycolipid biosurfactants produced by Pseudomonas aeruginosa, valued for their surface activity, biodegradability, and potential as green alternatives to synthetic surfactants. The first rhamnosylation step, catalyzed by RhlB, is central to the catalytic efficiency of monorhamnolipid formation and subsequent dirhamnolipid biosynthesis. To explore natural diversity and enhance RhlB activity, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41996192
DOI: 10.1021/acssynbio.5c00828
PMCID: PMC13185158

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