Article
Ubiquinone-based gene mutation and protein compactness of CoQ5 may contribute to a novel caspofungin resistance mode in Aspergillus flavus from pulmonary aspergillosis.
Diagnostic microbiology and infectious disease - 1 May 2026
Salehi Zahra, Seyedjavadi Sima Sadat, Hasannejad-Asl Behnam, Sharifynia Somayeh, Shams-Ghahfarokhi Masoomeh, Esfahani Aida, Poorabdollah Mihan, Eslamifar Ali, Marjani Majid, Jamzivar Fatemehsadat, Goudarzi Mehdi, Tabarsi Payam, Razzaghi-Abyaneh Mehdi
Abstract excerpt
Invasive pulmonary aspergillosis (IPA), primarily caused by Aspergillus fumigatus and A. flavus, is a life-threatening fungal infection with high mortality rates. This study investigated novel resistance mechanisms to caspofungin (CAS) in clinical Aspergillus isolates with particular focus on genetic alterations in the CoQ5 gene and their functional implications. One hundred and forty-eight Aspergillus isolates...
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