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Article

An integrative spatial multi-omic workflow for unified analysis of tumor tissue.

Cell reports methods - 23 Feb 2026

Kriel Jurgen, Moffet Joel J D, Lu Tianyao, Fatunla Oluwaseun E, Narayana Vinod K, Valkovic Adam, Maluenda Ana, McConville Malcolm J, Tsui Ellen, Whittle James R, Best Sarah A, Freytag Saskia

Abstract excerpt

Combining molecular profiling with imaging techniques has advanced the field of spatial biology, offering new insights into complex biological processes. Focusing on diffuse IDH-mutated glioma, this study presents a workflow for spatial multi-omics integration (SMINT) specifically combining spatial transcriptomics and spatial metabolomics. Our workflow incorporates both existing and custom-developed computational...

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Identifiers

PMID: 41687601
DOI: 10.1016/j.crmeth.2026.101306
PMCID: PMC12946760

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