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Article

Essential Role of LapD in the Absence of Cardiolipins.

International journal of molecular sciences - 31 Jan 2026

Raina Satish, Maniyeri Akshay, Ayyolath Aravind, Klein Gracjana

Abstract excerpt

To maintain the integrity of the outer membrane of Gram-negative bacteria, such as Escherichia coli, the levels of two essential components, phospholipids (PL) and lipopolysaccharide (LPS), are tightly regulated, although the underlying molecular mechanisms are unclear. E. coli synthesizes three main PLs, including essential phosphatidylethanolamine and phosphatidylglycerol and nonessential cardiolipin (CL). We...

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Identifiers

PMID: 41683866
DOI: 10.3390/ijms27031445
PMCID: PMC12898747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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