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Article

Transcriptional Reprogramming of Staphylococcus aureus in Chronic Rhinosinusitis Reveals a Persistence-Associated Phenotype.

International journal of molecular sciences - 31 Jan 2026

Tuchscherr Lorena, Monecke Stefan, Jundzill Mateusz, Hölzer Martin, Brandt Christian, Wendler Sindy, Priese Juliane, Ehricht Ralf, Guntinas-Lichius Orlando

Abstract excerpt

Chronic rhinosinusitis (CRS) is a persistent inflammatory condition frequently associated with Staphylococcus aureus. The bacterium's ability to evade immune clearance and establish long-term infection complicates treatment. In our previous study, we demonstrated that S. aureus isolates obtained from patients with CRS (CRS-S. aureus isolates; CSS) exhibit reduced glycolytic activity and cytotoxicity, which is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41683851
DOI: 10.3390/ijms27031429
PMCID: PMC12897772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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