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Article

Enhanced Monacolin K Production in Monascus purpureus Via Mutagenesis and Nitrogen Source Optimization.

Journal of basic microbiology - 1 Feb 2026

Yang Chen, Yajing Yang, Housheng Hong

Abstract excerpt

Monascus fungi are valued for their production of Monacolin K (MK), a bioactive compound with recognized lipid-lowering and multifunctional properties. To enhance MK yield in solid-state fermentation, this study combined atmospheric and room-temperature plasma (ARTP) mutagenesis with L-arginine supplementation. A mutant strain, C-23, was obtained, and the addition of L-arginine increased MK production by 97.3%,...

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Identifiers

PMID: 41674370
DOI: 10.1002/jobm.70151
PMCID: PMC12895299

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