Identification of single nucleotide polymorphisms in sheep Mx genes: A premature stop codon abolishes Mx2 protein expression but did not affect fertility and early animal development.

Abstract excerpt

Mx proteins are interferon-induced GTPases that inhibit a wide range of viruses. The loss of functional Mx genes in mice and other model species is associated with inferior innate immune responses and increased virus susceptibility. Here, we describe genetic variations in the Mx genes of sheep (Ovis aries). More than 700 single nucleotide polymorphisms within or adjacent to MX1 and MX2 were identified by...

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