Article
Reduced lentivirus susceptibility in sheep with TMEM154 mutations.
PLoS genetics - 1 Jan 2012
Heaton Michael P, Clawson Michael L, Chitko-Mckown Carol G, Leymaster Kreg A, Smith Timothy P L, Harhay Gregory P, White Stephen N, Herrmann-Hoesing Lynn M, Mousel Michelle R, Lewis Gregory S, Kalbfleisch Theodore S, Keen James E, Laegreid William W
Abstract excerpt
Visna/Maedi, or ovine progressive pneumonia (OPP) as it is known in the United States, is an incurable slow-acting disease of sheep caused by persistent lentivirus infection. This disease affects multiple tissues, including those of the respiratory and central nervous systems. Our aim was to identify ovine genetic risk factors for lentivirus infection. Sixty-nine matched pairs of infected cases and uninfected...
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