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Article

Systematic generation of Drosophila Wnt transgenes enables the characterization of canonical Wnt signaling.

Fly - 1 Dec 2026

Little Jamie C, Debrunner Marc, de Hoog Thom, Tadjik Farzad, Kehl Chiara J, Hausmann George, Brunner Erich, Basler Konrad

Abstract excerpt

A conserved cohort of signalling pathways orchestrate development and adult homoeostasis. Deregulation of these pathways underlies many diseases. A key set of signals is the family of Wnt ligands. Members of this family are conserved, but a clear understanding of the unique and redundant roles is lacking. Previous efforts to study Wnt ligand function in Drosophila have been hampered by the difficulty of...

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PMID: 41667411
DOI: 10.1080/19336934.2026.2624185
PMCID: PMC12893696

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