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Article

Non-small cell lung carcinomas with diffuse co-expression of TTF-1 and p40: Clinical, pathological and molecular characterization of a tumor subtype.

Virchows Archiv : an international journal of pathology - 1 Apr 2026

Sun Leina, Cui Yuechen, Zhang Zhanshuo, Wang Shuo, Zhang Bin, Cao Wenfeng, Yue Dongsheng

Abstract excerpt

Lung cancer is typically classified based on morphological characteristics and immunoprofile. When histologic differentiation is difficult, immunohistochemical staining serves as a valuable diagnostic tool. Although most cases show distinct marker expression patterns, rare instances exhibit co-expression of both TTF-1 and p40. Moreover, for this particular subtype of non-small cell lung cancer (NSCLC), no clear...

Topics

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Biomarkers, Tumor
Carcinoma, Adenosquamous
Carcinoma, Non-Small-Cell Lung
Immunodominant Epitopes
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptide Fragments

Thyroid Nuclear Factor 1

Source

Identifiers

PMID: 41665643
DOI: 10.1007/s00428-026-04436-y

Genes

TMEM132C
TNN
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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