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Article

Development of lung adenocarcinomas with exclusive dependence on oncogene fusions.

Cancer research - 1 Jun 2015

Saito Motonobu, Shimada Yoko, Shiraishi Kouya, Sakamoto Hiromi, Tsuta Koji, Totsuka Hirohiko, Chiku Suenori, Ichikawa Hitoshi, Kato Mamoru, Watanabe Shun-Ichi, Yoshida Teruhiko, Yokota Jun, Kohno Takashi

Abstract excerpt

This report delivers a comprehensive genetic alteration profile of lung adenocarcinomas (LADC) driven by ALK, RET, and ROS1 oncogene fusions. These tumors are difficult to study because of their rarity. Each drives only a low percentage of LADCs. Whole-exome sequencing and copy-number variation analyses were performed on a Japanese LADC cohort (n = 200) enriched in patients with fusions (n = 31, 15.5%), followed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25855381
DOI: 10.1158/0008-5472.CAN-14-3282

Genes

ALK
RET
ROS1

Provenance

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