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Article

Prognostic impact of myelodysplasia-related gene mutations in FLT3-ITD-mutated acute myeloid leukemia.

Leukemia - 1 Mar 2026

Mecklenbrauck Rabea, Villaverde Ramiro Angela, Sträng Eric, Gabdoulline Razif, Martinez Elicegui Javier, Sobas Marta, Pleyer Lisa, Turki Amin, Voso Maria Teresa, Benner Axel, Hernández-Sánchez Alberto, Tettero Jesse M, Tur Gimenez Laura, Metzeler Klaus H, Oñate Guadalupe, Lehmann Sören, Huntly Brian Jp, Thomas Ian, Thol Felicitas R, Heidel Florian H, Valk Peter Jm, Döhner Konstanze, Haferlach Torsten, Mills Kenneth I, Döhner Hartmut, Castellani Gastone, Ossenkoppele Gert J, Hernández-Rivas Jesus María, Bullinger Lars, Heuser Michael

Abstract excerpt

The inclusion of nine myelodysplasia-related gene (MRG) mutations (ASXL1, BCOR, EZH2, RUNX1, SF3B1, SRSF2, STAG2, U2AF1, ZRSR2) as adverse risk factors in the ELN risk classification has reshaped classification in acute myeloid leukemia (AML). AML with FLT3-ITD mutations and co-occurring MRG alterations is now classified to the ELN adverse risk group although supporting evidence remains limited. Among 4,078...

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fms-Like Tyrosine Kinase 3
STAG2 gene
Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myelodysplastic Syndromes

Nuclear Proteins

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Identifiers

PMID: 41663622
DOI: 10.1038/s41375-026-02874-w
PMCID: PMC12960240

Genes

FLT3
ELN
NPM1
ASXL1
BCOR
RUNX1
SF3B1
SRSF2
STAG2
U2AF1
ZRSR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Prognostic impact of myelodysplasia-related gene mutations in FLT3-ITD-mutated acute myeloid leukemia.PMID 41663622Read ↗

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